Most of the protein-coding genes, those that are transcribed with the help of RNA plymerase II, possess in their promoter core-region a sequenece known as the TATA box. This sequence placed around 30 nucleotides upstream of the transcription initiation site, allows the incorporation of RNA polymerase II to the DNA strand with the help of a set of coupling proteins (TATA box binding protein -TBP- and TBP associated factors). Once the whole transcription complex is assambled onto the DNA molecule, the RNA polymerase II needs to be phophorilated in its C terminal domain so the complex can leave the promoter region and initiate transcription. Other sequences, besides the TATA box, important for transcription complex formation can be found in other eukaryotic genes. Video obtained from Youtube.
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